John Guatelli, M.D.

University of California San Diego


Dr. Guatelli is Professor of the Division of Infectious Diseases at the University of California San Diego (UCSD), where he also received his M.D. and clinical training in infectious disease medicine. Dr. Guatelli is a leading expert in the HIV accessory proteins Vpu and Nef, which he has studied for more than 15 years.  Dr. Guatelli first reported the essential role of Nef in HIV replication, and then discovered how Nef modulates the cellular machinery to alter the trafficking of CD4 and other host proteins. He recently identified the cellular restriction factor that the HIV-1 Vpu protein counteracts to enhance HIV replication. He is the author of more than 50 publications in these topics. Dr. Guatelli is a permanent member of the AIDS Molecular and Cellular Biology review panel of the National Institutes of Health.